Abstract #3770

Three-Dimensional Free-breathing Whole-Liver Simultaneous T1, R2*, and Fat-Fraction Quantification Using MR Multitasking

Nan Wang^1,2, Anthony G Christodoulou¹, Yibin Xie¹, Fei Han³, Xiaodong Zhong³, Sen Ma^1,2, Xiaoming Bi³, Vibhas Deshpande⁴, and Debiao Li¹

¹Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States, ²Bioengineering, University of California, Los Angeles, Los Angeles, CA, United States, ³Siemens Healthcare, Los Angeles, CA, United States, ⁴Siemens Healthcare, Austin, TX, United States

Quantitative MRI has been playing a key role in the assessment and characterization of liver. However, current applications are still facing technical challenges. In this work, we proposed a novel technique based on MR Multitasking, which enables simultaneous T1, R2*, and FF quantification in one scan with free-breathing acquisition, 3D whole-liver coverage, and sufficient spatial resolution. The feasibility of the proposed method were demonstrated on the volunteer study (N = 8), showing that the T1, R2*, and FF quantification was repeatable in vivo and consistent with the results from the reference methods.

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