Abstract #3842

BOLD and CBV nonlinear responses during a hand movement task with increasing movement rates using 3D-EPI VASO at 7T

Ícaro A F de Oliveira^1,2, Wietske van der Zwaag¹, Luisa Raimondo¹, Serge O Dumoulin^1,2,3, and Jeroen CW Siero^1,4

¹Spinoza Centre for Neuroimaging, Amsterdam, Netherlands, ²Experimental and Applied Psychology, VU University, Amsterdam, Netherlands, ³Experimental Psychology, Helmholtz Institute, Utrecht University, Utrecht, Netherlands, ⁴Radiology, University Medical Centre Utrecht, Utrecht, Netherlands

We used 3D-EPI VASO to simultaneously measure CBV and BOLD signal changes in the primary motor cortex. We aimed to investigate differences in neurovascular coupling as measured by BOLD and CBV signal changes during a hand movement task with increasing movement rates. In agreement with previous findings, the BOLD response was found to behave nonlinearly with respect to the movement rate. Remarkably, the CBV response amplitude also shows a similar and strong nonlinear behavior where the amplitude saturates at fast movement rates (≥ 1 Hz).

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