Abstract #3864

Beyond the limits of layer-dependent CBV fMRI in humans: strategies towards whole brain coverage, sub-second TR, and very high 0.5mm resolutions

Laurentius Huber¹, Yuhui Chai², Rüdiger Stirnberg³, Sriranga Kashyap¹, Deni Kurban¹, Arman Khojandi², Dimo Ivanov¹, Sean Marrett², Tony Stöcker^3,4, Kamil Uludag⁵, Peter Bandettini², and Benedikt Poser¹

¹MR-Methods group, MBIC, Faculty of Psychology and Neuroscience, Maastricht, Netherlands, ²SFIM, NIMH, Bethesda, MD, United States, ³German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany, ⁴Physics and Astronomy, University of Bonn, Bonn, Germany, ⁵UHN Toronto, Toronto, ON, Canada

Recent developments of ultra-high field (UHF) MRI and high-resolution CBV-sensitive VASO sequences have made it possible to measure activity changes across cortical depths. However, most methods are limited to individual brain areas of large cortical thicknesses (4mm in M1), long repetition times and small matrix sizes. In this study, we developed multiple VASO sequence approaches to achieve:

1.) Whole-brain coverage (104 slices) at sub-millimeter layer resolutions

2.) Sub-second TRs (TR = 650ms) at sub-millimeter layer resolutions

3.) Extra-high 0.5mm isotropic resolutions with matrix sizes of 316

We tested new sequence concepts and validated their applicability for the neuroscientific context.

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