Recent developments of ultra-high field (UHF) MRI and high-resolution CBV-sensitive VASO sequences have made it possible to measure activity changes across cortical depths. However, most methods are limited to individual brain areas of large cortical thicknesses (4mm in M1), long repetition times and small matrix sizes. In this study, we developed multiple VASO sequence approaches to achieve:
1.) Whole-brain coverage (104 slices) at sub-millimeter layer resolutions
2.) Sub-second TRs (TR = 650ms) at sub-millimeter layer resolutions
3.) Extra-high 0.5mm isotropic resolutions with matrix sizes of 316
We tested new sequence concepts and validated their applicability for the neuroscientific context.