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Abstract #3920

Evidences of Disrupted Temporal Variabilities in patients with subjective cognitive decline: a resting-state fMRI study

Ling Zhang 1, Yi Zhu 2, Han Wu 3, Hongyuan Ding 1, Yaxin Gao 4, Qian Zhong 4, Qiumin Zhou 2, Ming Qi 1, Long Qian 5, Weiqiang Dou5, and Tong Wang2
1Radiology department, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China, 2Rehabilitation Department, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China, 3Rehabilitation Department, Nanjing Drum Tower Hospital, The Affiliated Hospital of the Medical School at Nanjing University, Nanjing, China, 4Nanjing Medical University, Nanjing, China, 5MR Research China, GE Healthcare, Beijing, China

In this study, the whole brain temporal variability (TV) changes have been respectively investigated for patients with subjective cognitive decline (SCD) and mild cognitive impairment (MCI) and healthy controls (HCs). Significantly different TVs have been separately found between SCD, MCI patients and HCs in the regions involved in executive function, episodic memory, visual processing and visual memory and language perception and processing. Additionally, the TVs at these regions also showed strong correlations with multiple clinical scales. Therefore, TV method can be considered an effective tool in the early detection of SCD patients.

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Abstract