BOLD fMRI is ideal for investigating neural plasticity of transgenic mouse lines. Visual and somatosensory functions can be reorganized following deafness in the early stage and adult in humans and animals. However, the extent of the neural plasticity remains unclear. To determine how deafness affects other sensory areas, 9.4T BOLD fMRI of sensory stimulation was measured before and after deafening in transgenic adult mice. The impact of scanner noise to evoked responses was also investigated in wild-type mice. Our results suggest that the sensory loss in one modality affects other sensory activities.