Ultra-fast 10 Hz whole brain fMRI with magnetic resonance encephalography (MREG) enables separation of cardiovascular waves from brain pulsation without temporal aliasing. This enables analysis of spectral characteristics of respiration and cardiovascular pulsations by extending ALFF and fALFF methods to cardiovascular and respiration frequencies . Modulation of the cardiovascular pulsation has been detected in ECG and SpO2 and in this study show the modulation of the cardiovascular brain pulsation in 3D brain in healthy controls and how age and blood pressure affects the modulation.
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