Single-shot EPI (SS-EPI) is widely used for diffusion-weighted imaging (DWI), but suffers from susceptibility-induced distortion and T2* blurring, which limit its resolution and ability to detect detailed structures. Parallel imaging and multi-shot techniques can be used to improve the resolution and reduce image distortion. However, these techniques have their own drawbacks, such as limited achievable acceleration factors or prolonged acquisition time. In this study, a deep-learning based method is proposed to achieve high-resolution distortion-free DWI using SS-EPI thus to improve the acquisition efficiency and clinical applicability.
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