Advanced diffusion MRI (dMRI) data with high resolution and strong diffusion contrast typically suffer from low SNR levels. Therefore, denoising algorithms such as MP-PCA became an essential part of current dMRI processing pipelines. To overcome challenges related to violations of MP-PCAs assumption of tissue homogeneity in typical dMRI data, we here introduce an informed-MP-PCA (iMP-PCA) algorithm taking local differences in tissue composition into account. Denoising-performance of iMP-PCA was compared to conventional MP-PCA and evaluated on both magnitude and real-valued dMRI data. iMP-PCA was shown to significantly improve denoising-performance, especially at tissue boundaries and in regions of low SNR.