Abstract #4384

A Study on Time Dependency of the Fractional Order Calculus Diffusion Model

Guangyu Dan^1,2, Yuxin Zhang^3,4, Zheng Zhong^1,2, Kaibao Sun¹, M. Muge Karaman^1,2, Diego Hernando^3,4, and Xiaohong Joe Zhou^1,2,5

¹Center for Magnetic Resonance Research, University of Illinois at Chicago, Chicago, IL, United States, ²Department of Bioengineering, University of Illinois at Chicago, Chicago, IL, United States, ³Department of Medical Physics, University of Wisconsin-Madison, Madison, WI, United States, ⁴Department of Radiology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, United States, ⁵Department of Radiology and Neurosurgery, University of Illinois at Chicago, Chicago, IL, United States

Parameters in many diffusion models depend on diffusion time. However, time-dependent diffusion behaviors in the long diffusion time regime have not been well studied because a longer diffusion time would lead to a longer TE, substantially reducing signal-to-noise ratio in conventional spin-echo diffusion pulse sequences. In this study, we employed a STEAM diffusion sequence to investigate the diffusion-time dependence of parameters in a fractional order calculus diffusion model. Our results showed substantial dependence of all diffusion parameters on diffusion times in the range of 100-1000 ms.

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