Free water elimination (FWE) for diffusion tensor imaging (DTI) aims to decouple the free water contribution from tissue's diffusion. Recent studies suggest that FWE-DTI is essential to characterize degenerative processes since it suppresses free water partial volume effects from DTI analysis and provides an index sensitive to edema and tissue degeneration. In this work, the state-of-the-art of FWE-DTI estimation is explored and several fitting procedures are tested on in vivo data to which simulated lesions were added. We found that, unlike the multi-shell approach, the single-shell implementation was unable to discriminate between changes in tissue diffusion and free water increases.
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