White Matter Tract Integrity (WMTI) is a biophysical model with specificity to underlying tissue microstructures. However, recent work has suggested that inter-compartmental water exchange may affect outcomes of the model metrics. In this work, we analytically relate the WMTI-derived dMRI metrics to membrane permeability, and validate our predictions using Monte Carlo simulations. Our results show that the water exchange has a non-trivial effect on the metrics and needs to be carefully considered in WMTI.
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