Temporal Diffusion Ratio (TDR) is a novel technique introduced by Dell’Acqua et al. at ISMRM 2019, with potential for mapping areas with large diameter axons in the human brain. We aim to maximise TDR signal in practical applications by optimizing the sequence parameters used. Working in simulation, it is found that the highest TDR signal for a given axon diameter is produced by contrasting signal from sequences with as disparate as possible shapes: a tall/narrow gradient shape should be contrasted with a short/wide gradient to produce the best contrast.
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