We extend the diffusion tensor distribution imaging framework so that each subdomain making up the tissue is represented by an effective confinement (rather than diffusion) tensor. The confinement tensor is determined by the subdomain’s shape as well as the acquisition parameters and is the physical quantity that leads to microscopic diffusion anisotropy. In this approach, the scalar-valued diffusivity remains as an independent parameter, which could be different in different subdomains. We demonstrate the difficulties in estimating compartment-specific diffusivity alongside the confinement tensor distribution when typical free gradient waveforms are employed.
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