Abstract #4456

Scan-Rescan Reliability of Microstructural Imaging Metrics Derived from High-Gradient Diffusion MRI

Maya Polackal¹, Qiyuan Tian^1,2, Chanon Ngamsombat^1,2,3, Aapo Nummenmaa^1,2, Thomas Witzel^1,2, Eric C. Klawiter^2,4, Susie Y. Huang^1,2,5, and Qiuyun Fan^1,2

¹Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, ²Harvard Medical School, Boston, MA, United States, ³Department of Radiology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Thailand, ⁴Department of Neurology, Massachusetts General Hospital, Boston, MA, United States, ⁵Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, United States

Scan-rescan reliability of axon diameter index, restricted volume fraction, and DTI metrics derived from high-gradient diffusion MRI was assessed in seven healthy volunteers. Maps of all three metrics were visually comparable from scan/rescan sessions, and moderate to high voxel-wise correlation coefficients were obtained for all metrics. Intraclass correlation coefficients were high for well-defined white matter tracts across all subjects. Our preliminary findings support the robustness and reliability of high-gradient diffusion MR metrics for use in clinical research studies.

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