Double diffusion encoding (DDE) can measure the microscopic anisotropy (μFA), however one of problems for clinical application is that the acquisition time is prolonged due to the many diffusion encoding patterns necessary. Recently, DDE with a reduced number of acquisitions has been proposed as a solution and been validated as a solution at 9.4T. The aim of this study is to validate the proposed solution for clinical application on 3T clinical scanners. Our results show that our proposed solution can obtain more accurate μFA than previous reported solutions on 3T clinical scanners.
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