Diffusion MRI is a powerful tool to investigate the structural connectivity of the brain. Ultra-high field preclinical MRI systems are equipped with strong gradients that allow to reach higher spatial and angular resolutions in animal models, enabling to segment white matter bundles in a similar way to what was achieved in humans. In this study, we propose to adapt the clustering approach of Guevara to rodents to establish a novel atlas of the connectivity of C57BI6 mice brains. 3D Hybrid diffusion imaging was performed ex-vivo allowing the reconstruction of a novel white matter atlas including 25 well-described fiber bundles.
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