The white matter organization of anterior nuclei of thalamus (ANT) has not been comprehensively examined before. We visualized white matter tracks in Papez circuit determining different ROIs in ANT, cingulate gyrus, mammillothalamic body, hippocampus and parahippocampal region for ANT-DBS in epilepsy. We employed constrained spherical deconvolution (CSD), multi-shell multi-tissue (MSMT) CSD, and DTI model to characterize white matter tissue organization in healthy controls and one patient diagnosed with refractory epilepsy in DW-MRI. We demonstrate a connectivity pattern of ANT. CSD model tractography may provide consistent insights on the alteration of the connections in patients with refractory epilepsy for performing ANT-DBS.