In a population of 260 elderly individuals presenting white matter hyperintensities of presumed vascular origin, lesion profile along reconstructed tracts correlated strongly with diffusion metrics obtained from multishell acquisition (notably intracellular volume fraction, orientation dispersion index, axial radial and mean kurtosis). Results appeared stronger when the tractography was performed using data from the highest b-value. Furthermore, changes to the diffusion signal was observed consistently on the reconstructed tracts at the vicinity of the lesions potentially indicative of tissue vulnerability beyond the lesion border identified from FLAIR images.
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