The aim of this study is to analyze differences in the hyperdirect cortical connectivity between the subthalamic nucleus and its medial region, and the anatomo-functional organization of these regions using tractography. These analyzes were performed in healthy subjects and parkinsonian patients. Our results show that a dominant motor cluster was located in the posterolateral STN, a limbic cluster located medially in the MSR, and an intermediate motor-limbic cluster located in between for both cohorts. In conclusion, tractography based sub-parcellisation of subthalamic regions could be helpful to refine individual targeting for functional neurosurgery.
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