This prospective study aimed to evaluate the value of MRI in prenatal diagnosis of cleft lip and palate. Pregnant females subject with fetal facial malformations were suspected by ultrasonography (US) and then underwent 1.5 T MRI scan. The diagnosis accuracy of the prenatal US and MRI was compared with the postnatal findings. A total of 44 fetuses were followed up with lip and/or cleft palate malformation. Compared to US, MRI provides more useful information in the diagnosis of fetal cleft lip and palate，which could be used as one of the effective alternative to prenatal ultrasound diagnosis．
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