Analyzing fetal brains with Down syndrome is an interesting are because genetic factors affect brain development in early fetal stages. In addition to cortical volumetric and areal measures used in our previous studies, cortical folding in the fetal brain would be an important marker of altered neurodevelopment due to Down syndrome. Thus, we calculated sulcal depth to quantify cortical folding and compared sulcal depth between Down syndrome and typically developing fetuses. Down syndrome fetuses showed significantly altered sulcal depth compared to typically developing peers in the regions related to decreased neurogenesis in early fetal life.
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