Diffusion-weighted imaging (DWI) is an essential MR sequence for evaluating pediatric patients with moyamoya disease (MMD). Acoustic noise associated with DWI may lead to motion artifact. Compared with conventional DWI (cDWI), quiet DWI (qDWI) is considered less noisy and able to keep children more relaxed and stable. We evaluated the advantages of qDWI compared with cDWI in pediatric MMD patients. Compared with cDWI, qDWI induced fewer artifacts in sedated pediatric MMD patients, whereas in unsedated patients, the frequencies of qDWI- and cDWI-induced artifacts were similar. qDWI and cDWI had the same performance for detecting restricted diffusion.