Abstract #4683

Differentiation of Low- and High-Grade Pediatric Brain Tumors with Amide Proton Transfer Imaging

Xingwang Yong¹, Hongxi Zhang², Zhipeng Shen³, Xinchun Chen², Weibo Chen⁴, Dan Wu¹, and Yi Zhang¹

¹Key Laboratory for Biomedical Engineering of Ministry of Education, Department of Biomedical Engineering, College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou, Zhejiang, China, ²Department of Radiology, Children’s Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China, ³Department of Neurosurgery, Children’s Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China, ⁴Philips Healthcare, Shanghai, China

Amide proton transfer (APT) imaging was applied to the grading of pediatric brain tumors for the first time with its performance evaluated by the Receiver Operating Characteristic (ROC) curve. Ninety-two patients were enrolled in this study, of whom 48 cases were high-grade tumors and 44 cases were low-grade tumors. An experienced radiologist delineated the initial ROIs, which were then automatically masked and shrunk to avoid artifacts and subjective bias. APT MRI was able to differentiate low-grade pediatric brain tumors from high-grade ones, with a maximum area under the ROC curve of 0.95 in conjunction with quantitative T1 and T2.

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