Abstract #4701

Fibre specific tract profiles of children with ADHD: Evidence from fixel-based analysis

Ian Fuelscher¹, Emma Sciberras^1,2,3, Daryl Efron^2,3,4, Vicki Anderson^4,5, Christian Hyde¹, and Timothy J Silk^1,4,5

¹School of Psychology, Deakin University, Geelong, Australia, ²Population Health, Murdoch Children's Research Institute, Melbourne, Australia, ³Department of Paediatrics, University of Melbourne, Melbourne, Australia, ⁴The Royal Children's Hospital, Melbourne, Australia, ⁵Clinical Sciences, Murdoch Children's Research Institute, Melbourne, Australia

Diffusion tensor imaging (DTI) studies examining white matter microstructure in children with attention-deficit/hyperactivity disorder (ADHD) have provided conflicting results, possibly reflecting limitations of the DTI framework. We leverage fixel-based analysis (FBA), a fibre specific assessment of white matter microstructure, to comprehensively evaluate white matter tract profiles of children with ADHD. Relative to controls, children with ADHD show both reduced fibre density and reduced fibre cross section across association, projection and commissural fibres. FBA metrics further correlate with ADHD symptom severity. We conclude that ADHD symptomatology in childhood may be subserved by altered communication pathways across the brain.

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