This work quantitatively and qualitatively assesses the relation between tumor related cellularity variation and ADC values. We show that the ADC slope along linear profiles perpendicular to the boundary voxels of the ADC region of interest is a a biomarker of tumor infiltration beyond the contrast enhancing regions. We demonstrate the existence of a strong relation between ADC and tumor cellularity and show that a vectorial profile analysis of ADC maps could provide with a robust biomarker of glioblastoma cell infiltration.
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