Abstract #4842

A descriptive study to evaluate radiotherapy-related response for myxoid liposarcomas using functional MRI

Evanthia Kousi¹, Christina Messiou¹, Aisha Miah², Matthew Orton¹, Rick Haas^3,4, Khin Thway², Georgina Hopkinson¹, Shane Zaidi², Myles Smith², Elizabeth Barquin², Eleanor Moskovic², Nikolaos Fotiadis², Dirk Strauss², Andrew Hayes¹, and Maria A Schmidt¹

¹The Royal Marsden NHS Foundation Trust and Institute of Cancer Research, London, United Kingdom, ²The Royal Marsden NHS Foundation Trust, London, United Kingdom, ³The Netherlands Cancer Institute, Amsterdam, Netherlands, ⁴The Leiden University Medical Center, Leiden, Netherlands

Summary: Myxoid liposarcomas (MLS) show enhanced radiotherapy response owing to their distinctive vasculature. We explore the role of functional MRI in identifying MLS response to radiotherapy.

Methods: Ten patients with histologically-proven MLS received radiotherapy. Diffusion, T2* and vascularity estimates were assessed at pre-, during and post-radiotherapy.

Results: Baseline values and post-radiotherapy changes of [Gd], IAUGC60 and Ktrans were statistically different between responders and non-responders but not ADC. Responders demonstrated statistically significant early tumour volume and post-radiotherapy T2* reductions.

Conclusion: Baseline vascularity estimates and their post-radiotherapy changes could predict MLS response. Early volume changes precede changes in MLS functionality.

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