Lipid composition in breast has a major role in breast cancer prevention, with deregulation of lipid metabolism identified in BRCA1/2 genetic mutation carriers. Neoplastic tubule formation can infiltrate adipose tissue in peri-tumoural region, with low tubular differentiation indicating a poorer prognosis. Lipid composition measurement through biochemical extraction is invasive, while conventional chemical shift imaging demands an intolerably long acquisition time. Recent development in gradient-echo (GRE) based imaging allows lipid composition mapping of the whole breast in a clinically acceptable timeframe. We set out to examine the relationship between peri-tumoural lipid composition and tubule formation using GRE-based imaging in breast tumours.
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