Abstract #0261

Cumulative effects of a statin cocktail on cerebral blood flow and cognitive function in patients with Alzheimer’s Disease

Mohammed Salman Shazeeb¹, Elizabeth Degrush^2,3, Zeynep Vardar¹, Clifford Lindsay¹, Matthew Gounis¹, and Nils Henninger^2,3

¹Department of Radiology, University of Massachusetts Medical School, Worcester, MA, United States, ²Department of Neurology, University of Massachusetts Medical School, Worcester, MA, United States, ³Department of Psychiatry, University of Massachusetts Medical School, Worcester, MA, United States

Decreased cerebral metabolism has been implicated in pathogenesis of Alzehimer’s disease. The endothelial nitric oxide synthase (eNOS) pathway plays a major role in cerebral blood flow regulation. This study used DSC-MRI in 10 patients treated with a drug regimen for supporting the eNOS pathway to investigate how perfusion patterns were associated with treatment response based on clinical psychometrics. Regional analysis on rCBF maps showed significant signal changes in the cognitively improved cohort based on ADAS-cog scores while patients that showed cognitive deterioration or no change based on ADAS-cog scores did not show significant rCBF changes.

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