In this study, we evaluated diffusion and kurtosis time-dependence for HPV-positive oropharyngeal squamous cell carcinoma before and during chemo-radiation treatment over a wide range for longer diffusion times (200-700 ms). The patients with less than 40% nodal volume shrinkage had significantly higher diffusivity at pretreatment and lower kurtosis at week4 than the patients with more than 40% nodal volume shrinkage. The water exchange times were 68-80 ms without a significant difference between the groups. This study demonstrates the feasibility of using diffusion MRI at relatively long diffusion times to predict and evaluate the response to chemo-radiation therapy.
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