Glutamate-weighted chemical exchange saturation transfer (GluCEST) imaging is a novel enhancement technique for the non-invasive detection and quantification of cerebral glutamate levels in neuro-molecular processes. The present study quantitatively evaluated glutamate signal changes in the hippocampal region of a rat forced swimming test model (FS) of depression. The GluCEST and proton magnetic resonance spectroscopy results showed that GluCEST values and glutamate concentrations were significantly lower in the FS rats than in the controls. These findings might provide a key marker to better understand the cerebral neurochemical responses in depressive disorders.
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