Multiple subcortical white matter areas showing impaired cerebrovascular reactivity (CVR) in our pre-symptomatic and early Huntington Disease (HD) subjects overlap with the white matter areas and tracts that have been reported to demonstrate altered microstructural integrity. They are also adjacent to cortical brain regions that atrophy as disease progresses in HD. Our findings support that abnormal cerebrovascular function contributes to the neuropathology of HD.
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