Abstract #0046

Optimization of perfusion measurements at 7 T using pulsed ASL with simultaneous multi-slice EPI readouts at multiple post-labelling delays

Dimo Ivanov¹, Sriranga Kashyap^1,2, Laurentius Huber¹, Josef Pfeuffer³, Kâmil Uludağ⁴, and Benedikt A Poser¹

¹Department of Cognitive Neuroscience, Maastricht University, Maastricht, Netherlands, ²Techna Institute, University Health Network, Toronto, ON, Canada, ³Siemens Healthineers, Erlangen, Germany, ⁴Techna Institute & Koerner Scientist in MR Imaging, Toronto, ON, Canada

Synopsis

Arterial spin labeling (ASL) at 7T is beneficial due to the higher signal-to-noise ratio (SNR) and the longer T₁ of blood and tissues. A whole-brain 7T pulsed ASL approach with simultaneous multi-slice (SMS) echo planar imaging readouts at multiple inversion times is presented. The interplay between the number of inversion times acquired, the total acceleration factor employed, and the temporal SNR was investigated. In summary, a protocol with in-plane acceleration factor 2 and SMS factor 2 offers the best compromise between perfusion tSNR and number of inversion times and can be used in clinical applications investigating perfusion parameters beyond CBF.

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