Abstract #0324
Contrast Agent Transport in Mouse Glymphatic System Observed by Dynamic Contrast-Enhanced MRI
Yuran Zhu1, Yuning Gu1, Kihwan Kim1, Chaitanya Kolluru1, Huiyun Gao2, Yunmei Wang2,3, David L. Wilson1,4,5, Chris A. Flask1,4,6,7,8, and Xin Yu1,4,9
1Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States, 2Cardiovascular Research Institute, Case Western Reserve University, Cleveland, OH, United States, 3Department of Medicine, Case Western Reserve University, Cleveland, OH, United States, 4Department of Radiology, Case Western Reserve University, Cleveland, OH, United States, 5Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, United States, 6Department of Pediatrics, Case Western Reserve University, Cleveland, OH, United States, 7Imaging Research Core, Case Western Reserve University, Cleveland, OH, United States, 8Cancer Imaging Program, Case Western Reserve University, Cleveland, OH, United States, 9Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH, United States
Synopsis
This study compared the transport of three MRI contrast agents with different molecular sizes (Gd-DTPA, GadoSpin, and H217O) in the mouse glymphatic system with dynamic contrast-enhanced MRI. Dynamic signal changes in the whole-brain and selected regions of interest (ROI) were analyzed. The results showed drastically different kinetics of the three tracers, indicating differences in glymphatic transport routes and rates. The current work lays the foundation for future studies employing genetically manipulated mouse models for mechanistic understanding of the regulation of glymphatic function in normal and diseased conditions.
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