Abstract #0397

Sub-0.1 microliter CBV fMRI on the Next Generation 7T scanner

David A Feinberg^1,2,3, Salvatore Torrisi^1,2, Alexander JS Beckett^1,2, Rüdiger Stirnberg⁴, Tony Stöcker⁴, Philipp Ehses⁴, and Renzo Huber³

¹Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA, United States, ²Advanced MRI Technologies, Sebastopol, CA, United States, ³Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, Netherlands, ⁴German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany

Synopsis

Laminar-specific fMRI with CBV-sensitive VASO can address neuroscience research questions on directional information processing within and across brain areas. However, conventional 0.8mm resolutions cannot Nyquist sample the individual layer-groups of interest (e.g. Layers II/III from layer IVc in V1). Here we implement, evaluate, and apply a 0.39-0.45mm (iso.) VASO protocol on the NextGen 7T scanner to resolve layer-features that could not be resolved in humans before. We find that 0.45 mm protocols are possible if the sequence parameters of EPI-segmentation and GRAPPA acceleration are differently optimized than one would do for conventional fMRI protocols.

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