In this study, we propose a novel pulse sequence to simultaneously acquire laminar ASL, VASO and T2-BOLD signals with high spatial resolution. Experiments were performed on the M1 to characterize concurrent layer-dependent CBF, CBV, T2 BOLD and CMRO2 signal changes to sensory input and motor output. Both positive CBF/CBV/CMRO2 and negative VASO profiles show a clear ‘double-peak’ pattern, which is consistent with the hypothesis that FT engages neural activity of somatosensory input in the superficial layers and motor output in the deep layers. The BOLD response mainly peaked in superficial layers due to dominant contribution of pial veins.
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