Dynamic glucose-enhanced deuterium MRS (DGE 2H-MRS) coupled with Marchenko-Pastur PCA denoising has shown potential for in vivo quantification of glucose metabolism through glycolysis and mitochondrial oxidation in a mouse model of glioblastoma, and for assessment of pathway flux modulations according to tumor heterogeneity. Here, we extend this approach to immunocompetent mouse glioblastoma subtypes with marked differences in tumor cell metabolism and histopathologic features, to utterly demonstrate the potential of DGE 2H-MRS for non-invasive metabolic phenotyping of glioma, or other cancers with mitochondrial oxidation dependencies, according to key features of the tumor microenvironment such as cell proliferation.
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