As atherosclerosis is one of the main causes of death in industrial nations, noninvasive imaging modalities for studying its underlying mechanisms are in great demand. The quantification of hemodynamic parameters such as pulse wave velocity (PWV) assessed by flow sensitive magnetic resonance imaging (MRI) is a promising tool to observe plaque progression in preclinical models. Mostly, a global PWV value is assessed, however, previous studies already pointed to heterogeneous elasticity profiles in the presence of atherosclerotic plaques. Here, we present the measurement of local PWV values in the murine aortic arch assessed by 4D-flow MRI for spatially resolved elasticity measurements.
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