Glutathione (GSH) is a brain marker for oxidative stress, which has previously been associated with brain amyloidosis and memory decline. However, to date no study has examined the link between GSH and beta-amyloid in a large cohort of elderly participants. Using simultaneous PET/MRS, we assessed amyloid deposition with amyloid-PET and GSH with MEGAPRESS, in a cohort of 134 healthy elderly and 46 mild cognitively impaired participants. GSH declined with age and showed sex differences, but no significant association between GSH and amyloid status was observed
This abstract and the presentation materials are available to members only; a login is required.