Abstract #1637

The relationship between hippocampal NAA and functional connectivity within the Default Mode Network in Mild Cognitive Impairment

Marilena M DeMayo^1,2, Jinglei Lv^1,2, Shantel Duffy^3,4, Sharon Naismith^3,4,5, and Fernando Calamante^1,2,6

¹School of Biomedical Engineering, University of Sydney, Sydney, Australia, ²Brain and Mind Centre, University of Sydney, Sydney, Australia, ³School of Psychology, University of Sydney, Sydney, Australia, ⁴Healthy Brain Ageing Program, Brain and Mind Centre, University of Sydney, Sydney, Australia, ⁵Centre of Research Excellence to Optimise Sleep in Brain Ageing and Neurodegeneration (CogSleep CRE), Sydney, Australia, ⁶Sydney Imaging, University of Sydney, Sydney, Australia

Synopsis

We investigated the association between two MR markers of Mild Cognitive Impairment (MCI): N-Acetylaspartate (NAA) measured by MR Spectroscopy within the hippocampus; and functional connectivity within the Default Mode Network (DMN). We showed differential relationships between functional coupling/connectivity and NAA in MCI and controls, with an association between these measures in MCI not evident in controls. For those with MCI, we detected 20 connections within the DMN associated with NAA levels, with stronger connectivity associated with lower NAA levels. This suggests change in NAA within the hippocampus is associated with functional change within the DMN for those with MCI.

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