Abstract #4032

Regional Brain Volumes, Cortical Thickness, Folding and Sulcal Depth in Perinatally HIV-Infected Youths

Ajin Joy¹, Manoj K Sarma¹, Jhelum Paul¹, Andres Saucedo¹, Paul M Macey², Dieter J Meyerhoff³, Ebrahim Haroon⁴, Margaret A Keller⁵, and M Albert Thomas¹

¹Radiological Sciences, University of California-Los Angeles, Los Angeles, CA, United States, ²School of Nursing and Brain Research Institute, University of California-Los Angeles, Los Angeles, CA, United States, ³Radiology and Biomedical Imaging, University of California-San Francisco, San Francisco, CA, United States, ⁴Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA, United States, ⁵Pediatrics, The Lundquist Institute, Harbor-UCLA Medical Center, Torrance, CA, United States

Synopsis

The human immunodeficiency virus (HIV) can affect the morphometry of the developing brain of perinatally HIV (PHIV)-infected youths. Surface-based morphometric analysis can reveal if local effects on gray and white matter volumes is significant in the regions with alterations in cortical thickness (CT), gyrification index (GI), or sulcal depth (SD). So, we compared these morphometric parameters of 19 PHIV-youths on combination antiretroviral therapy with those in 26 uninfected healthy controls. PHIV-youths had altered gray and white matter regional volume, CT, GI, and SD, partly in overlapping regions. The findings survived multiple comparisons using both false discovery rate and Holm-Bonferroni corrections.

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