Abstract #4589

Imaing the brain microstructures in patients of severe enlarged perivasclar spaces in the basal ganglia region using diffusion kurtosis imaging

Yuelei Lyu¹, Shuna Yang¹, Chen Zhang², Qinglei Shi², Guang Yang³, Wenli Hu¹, and Qi Yang¹

¹Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China, ²MR Scientific Marketing, Siemens Healthineers, Beijing, China, ³Shanghai Key Laboratory of Magnetic Resonance, School of Physics and Electronic Science, East China Normal University, Shanghai, China

Synopsis

This study used DKI to investigate possible microstructural alterations of brain tissues associated with plenty of EPVS in the basal ganglia (BG) in patients of SVD. Our preliminary results revealed that patients with EPVS in the BG showed significant reductions in kurtosis parameters from DKI and elevated diffusion parameters derived from DKI in bilateral putamen. We also found abnormal diffusion parameters in mainly bilateral BG, limbic system, temporal lobe,and other scatter brain regions. Our data suggests patients with plenty of EPVS in the BG might undergo microstructure impairments in the regions above, especially bilateral insular and BG.

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