Evaluation of early-stage knee osteoarthritis (OA) has long been of wide concern, while MRI has proved its value in this field by the richness of contrasts and non-invasive nature. However, MRI detection for composition change in OA still calls for deeper researches. ADC and T2 measured by conventional MRI are only an average of intra-voxel components and assumed to be independent. However, by performing a hybrid multidimensional MR imaging (HM-MRI) method, an implied correlation between ADC and T2 in articular cartilage has emerged. Moreover, Vnormal might offer extra information in detecting cartilage degeneration at early stage of OA than conventional ADC/T2 parameters.
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