Diffusion MRI provides opportunities in probing tissue microstructure based on mm-scale measurements. Generally, an MRI diffusion model is used to infer biologically meaningful information from diffusion MRI measurements. Recently, there has been increasing interest in mapping the so-called dot-compartment in the human brain. The dot-compartment has been ascribed to a tissue compartment which has highly restricted diffusion. Using a custom diffusion MRI line scan we investigated the ability to obtain high b-value signals using 3T MRI equipped with 80mT/m gradients. It appears that the dot-compartment is elusive when probed using clinical standard scanners even when b-values of 15000s/mm2 are achieved.
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