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Abstract #8017

Spectral Fitting & Absolute Quantification

Lana G. Kaiser1

1Siemens Japan KK, Tokyo, Japan

MRS quantification is complicated due to the metabolic resonance overlap and complex line shapes. The modern methods for the spectral fitting increasingly relies on the linear combination (LC) modeling algorithms. The absolute quantification can be carried out using internal or external concentration references. The challenges remain in the following areas: the generation of the accurate prior knowledge, creating proper model/constraints for data fitting algorithms and choice of more robust concentration references.

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