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Abstract #8064

Origins of BOLD - Neuroscience Perspectives

Anna Devor1,2

1Neurosciences and Radiology, UCSD, La Jolla, CA, United States, 2MGH/Harvard, Charlestown, MA, United States

Our ability to study human brain is limited by the necessity to use noninvasive technologies. This is in contrast to animal models where a detailed view of cellular-level brain function has become available due to recent advances in microscopic optical imaging and genetics. Thus, a central challenge facing neuroscience today is leveraging these mechanistic insights from animal studies to accurately draw physiological inferences from noninvasive signals in humans. On the essential path towards this goal is the development of a detailed “bottom-up” forward model bridging neuronal activity at the level of cell-type-specific populations to noninvasive imaging signals.

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