Radiomics is defined as: " “conversion of digital medical images into mineable high-dimensional data… motivated by the concept that biomedical images contain information that reflects underlying pathophysiology and that these relationships can be revealed via quantitative image analyses”. Radiomic features are comprised of imaging biomarkers (IB)Some key questions must be answered at an early stage: “Does the IB fulfill an unmet clinical need?”; “Does data exist to evaluate the IB and if not can it be obtained?”. At an early stage, technical validation including assessment of precision through repeatability and reproducibility must be determined. Furthermore, biologic and clinical validation must also be performed. Cost effectiveness must also be considered. The paradigm and consideraiton in radiomics research wil be reviewed.