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Abstract #0165

Measuring language laterality using functional connectivity

Abbott D, Jackson G, Shaw M, Waites A, Mannfolk P, Olsrud J
Brain Research Institute

Determination of language laterality index (LI) helps preserve function following neurosurgery. However, some subjects show little activation, or have difficulty performing the task. The purpose of the present study was to measure LI with functional connectivity, without using a language task. Twelve healthy subjects performed a verbal fluency task, together with a period of continuous rest. LI based only on resting data correlated with the conventional activation LI, and it was possible to threshold to distinguish typical from atypical LI with 100% concordance. This approach enables LI measurement in subjects of any age, and with decreased cognitive ability.