In vivo Staining of Apoptosis by Manganase-Enhanced Magnetic Resonance Imaging(MEMRI) in the Hypoxic-Ischemic Newborn Rat
Kim K, Kim J, Lim K, Cho H, Lee J
University of Ulsan College of Medicine
This study was designed to investigate the usefulness of MEMRI for in vivo detection of apoptosis for hypoxic-ischemic newborn rat brain. MEMRI showed high signal intensity regions at 72 hours after injury and Mn2+ administration. The signal intensity of the enhanced regions increased in time upto 1 week. Those enhanced regions in MRI were matched with TUNEL staining for apoptosis. The result of this study suggests that MEMRI can be an tool for in vivo staining of apoptosis.