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Abstract #0247

In-vivo 3T 1H magnetic resonance spectroscopy of the brain reveals elevated scyllo-inositol in patients with mild Alzheimers disease

Griffith H, Stewart C, den Hollander J, Evanochko W, Harrell L, Zamrini E, Marson D, Brockington J
University of Alabama at Birmingham

In-vivo 1H magnetic resonance spectroscopy (1H MRS) reveals brain metabolism abnormalities, including reduced N-acetylaspartate and elevated myo-inositol, in patients with mild Alzheimers disease (AD) and mild cognitive impairment (MCI). We are aware of no studies that have documented abnormal scyllo-inositol (sI) levels in AD and MCI. This study compared 3T 1H MRS of sI in the posterior cingulate gyrus across mild AD, MCI and healthy older adults. sI/ creatine (Cr) ratio was significantly higher in mild AD patients compared to controls, a finding not reported in past MRS studies. Further research with sI in AD appears warranted.