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Abstract #0260

Local Inflammatory Response due to Burn Coincides with Intramyocellular Lipid Accumulation

Tzika A, Cao H, Zhang Q, Yu H, Astrakas L, Mindrinos M, Tompkins R, Rahme L, Farrar C
Massachusetts General Hospital and Shriners Institute, Harvard Medical School, Massachusetts General Hospital, Harvard Medical School

We report that High Resolution Magic Angle Spinning (HRMAS) 1H MR Spectroscopy has detected intramyocellular lipid (IMCL) accumulation in burned versus normal mice. These IMCLs of the former were paralleled by increased expression of mitochondrial uncoupling protein 3 (UCP3) and increased levels of circulating fatty acids. Our findings are consistent with the hypothesis that IMCLs and UCP3 increase after burn in order to protect the myoskeletal mitochondria from the deleterious effect of increased mitochondrial matrix free fatty acids.